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KMID : 0359720110290030231
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Journal of the Korean Neurological Association
2011 Volume.29 No. 3 p.231 ~ p.233
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Myopathy with Anti Signal Recognition Particle Antibody
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Hong Hyun-jung
Sunwoo Il-Nam
Shin Ha-Young
Kim Se-Hoon
Cho Jeong-Hee
Kim Seung-Min
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Abstract
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Myopathies associated with anti-signal-recognition particle (SRP) antibodies usually present with severe muscle weakness and exhibit necrotizing myopathy with little inflammation pathologically. Here we report a case of a 61-year-old man who presented with subacute progressive proximal muscle weakness, dysarthria, and dysphagia. Although polymyositis was expected clinically, muscle biopsy revealed myopathic changes with degenerating fibers without definite inflammation. Further laboratory study revealed that the patient was positive for anti-SRP antibodies.
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KEYWORD
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Idiopathic inflammatory myopathies, Autoantibodies, Signal recognition particle
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